CDX1 Expression Induced by CagA-Expressing Helicobacter pylori Promotes Gastric Tumorigenesis
نویسندگان
چکیده
منابع مشابه
Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.
AIMS To use a range of natural phenotypically variant strains of Helicobacter pylori with disparate CagA and VacA (vacuolating cytotoxin) expression to determine which bacterial factors are more closely associated with epithelial interleukin-8 (IL-8) induction. METHODS Gastric epithelial cells (AGS and KATO-3) were co-cultured with five H pylori strains which were variously shown to express t...
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Gastric cancer development is strongly correlated with infection by Helicobacter pylori possessing the effector protein CagA. Using a transgenic Drosophila melanogaster model, we show that CagA expression in the simple model epithelium of the larval wing imaginal disc causes dramatic tissue perturbations and apoptosis when CagA-expressing and non-expressing cells are juxtaposed. This cell death...
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BACKGROUND AND AIMS It is not known why some people with Helicobacter pylori infection develop gastric cancer whereas others do not. Whether the CagA phenotype of H pylori infection affected risk for cancer independently of other posited risk factors was evaluated. SUBJECTS 242 persons who participated in a previous nested case-control study of gastric cancer. 179 (90 cases and 89 controls) w...
متن کاملHelicobacter pylori CagA induced interleukin-8 secretion in gastric epithelial cells
AIM Since, contradictory data have been reported about the effect of diverse variants of H. pylori virulence factors on IL-8 induction, we aimed to analyze the effect of this diversity on levels of IL-8 secretion in AGS cell line. BACKGROUND Helicobacter pylori colonizes the human stomach and induces the activation of inflammatory cytokines, including interleukin (IL)-8, in the gastric mucosa...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2019
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-19-0181